領域與內容

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研究領域

動脈粥樣化生成之機轉

抗發炎及抗氧化相關藥物之研究

心血管手術後之全身性發炎反應

心臟移植術後之血管病變及機轉

臨床試驗 (new drugs and medical materials development)

實驗模組

in vitro cell:

1. human coronary endothelial cells (HCAEC)

2. human aortic endothelial and smooth muscle cells (HAEC & HASMC)

3. human endothelial progenitor cells (HEPC)

4. human smooth muscle progenitor cells (HSMPC)

5. monocytic THP-1 and U937 cells

animal models:

1. rabbit aorta endolectomy

2. mouse hind limb ischemia

3. mouse aorta endolectomy

4. rat LAD ligation

5. high fat diet-induced atherosclerosis mouse

6. Neoangiogenesis gel in mouse

7. rat aorta transplantation

gene deficiency and transgenic mice:

1. B6.129P2-Nos3tm1Unc/J mice an eNOS knock-out mouse homozygous for the Nos3tm1Unc targeted mutation

2. C57BL/6-Tlr4lps-del mice a TLR4-knockout mouse homozygous for the defective LPS-response deletion allele Tlr4lps-del

3. B6.129P2-Apoetm1Unc N11 ApoE-knockout mouse

eGFP transgenic mice (ICR background)

Tie2-Cre and ROSA26-lacZ mice